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Herbs in The Formula

We meticulously find the best quality herbs and only use those that were tested for pesticide residues, heavy metals and verified for authenticity. The following herbs are used for the Formula for Pain (both the cream and the spray) and The Formula for Cramps (when noted in parenthesis). Additionally, studies on the pharmacological actions of the herbs are noted below as well.

Frankincense and Myrrh resin

Frankincense and Myrrh resin

AKA: Mo yao and Ru xiang

How it helps123

Corydalis Herb

Corydalis (in the Pain and Cramps Formula)

AKA: Yan hu suo

How it helps4

Homalomena

Homalomena

AKA: Qian nian jian
How it helps 56

Paniculate Swallowwort

Paniculate Swallowwort

AKA: Xu chang qing

How it helps7 8

Clematidis

Clematidis

AKA: Wei ling xian

How it helps9

Chinese Knotty Pine

Chinese Knotty Pine

AKA: Song jie

How it helps10

Star Jasmine Stem

Star Jasmine Stem

AKA: Luo shi tengHow it helps11 12

Sichuan Pepper

Sichuan Pepper (In both the Pain and Cramps Formula)

AKA: Hua jiao

How it helps131

Drynaria

Drynaria

AKA: Gu sui BuHow it helps 15

Safflower

Safflower (In both the Pain and Cramps Formula)

AKA: Hong hua
How it helps16

Angelica

Angelica (In both the Pain and Cramps Formula)

AKA: Dang gui wei
How it helps17

Dispacis

Dispacis

AKA: Xu duan
How it helps18 19

Skullcap

Skullcap

AKA: Huang qin
How it helps20

Motherwort (Cramps Formula only)

AKA: Yi mu caoHow it helps21
Reduces Uterine Spasms

Artemisia (Cramps Formula Only)

AKA: Ai Ye
How it helps22 23

Sappan Wood (Cramps Formula Only)

AKA: Su Mu
How it helps24

Licorice (Cramps Formula Only)

AKA: Gan Cao
How it helps25 26

Wild Angelica (Cramps Formula Only)

AKA: Bai Zhi
How it helps27

__________

[1] Su S, Duan J, Chen T, et al. Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway. Sci Rep. 2015;5:13668. doi:10.1038/srep13668

[2] Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. | DrugBank Online. Accessed November 3, 2021. https://go.drugbank.com/articles/A19618

[3] Cheng YW, Cheah KP, Lin CW, et al. Myrrh mediates haem oxygenase-1 expression to suppress the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. J Pharm Pharmacol. 2011;63(9):1211-1218. doi:10.1111/j.2042-7158.2011.01329.x

[4] Corydalis - an overview | ScienceDirect Topics. Accessed November 3, 2021. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/corydalis

[5] Barua CC, Talukdar A, Phukan B, Hazarika S, Barua AG, Baishya G. Phytochemical screening and in vitro antioxidant activity of ethanolic extract of Homalomena aromatica (Araceae) root. Published online 2014:11.

[6] Kehie M, Kehie P, Pfoze NL. Phytochemical and ethnopharmacological overview of endangered Homalomena aromatica Schott: An aromatic medicinal herb of Northeast India. Published online 2017:14.

[7] Xu L, Lao LX, Ge A, Yu S, Li J, Mansky PJ. Chinese Herbal Medicine for Cancer Pain.Integr Cancer Ther.2007;6(3):208-234. doi:10.1177/1534735407305705

[8] Zhou X, Xia W, Zhang Y, et al. Cynanchum paniculatum (Bunge) Kitag. ex H. Hara: A review of its ethnopharmacology, phytochemistry and pharmacology.J Ethnopharmacol.2020;260:112994. doi:10.1016/j.jep.2020.112994

[9] Wu W, Xu X, Dai Y, Xia L. Therapeutic effect of the saponin fraction from Clematis chinensis Osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage.Phytother Res.2010;24(4):538-546. doi:10.1002/ptr.2977

[10] Marcus A.Foundations for Integrative Musculoskeletal Medicine: An East-West Approach.North Atlantic Books; 2004.

[11] Choi JN, Choi YH, Lee JM, et al. Anti-inflammatory effects ofβ-sitosterol-β-D-glucoside from Trachelospermum jasminoides(Apocynaceae) in lipopolysaccharide-stimulated RAW 264.7 murinemacrophages.Nat Prod Res.2012;26(24):2340-2343.doi:10.1080/14786419.2012.654608

[12] Sheu MJ, Chou PY, Cheng HC, et al. Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae).J Ethnopharmacol.2009;126(2):332-338. doi:10.1016/j.jep.2009.08.019

[13] Wu G, Wu H. Analgesia Synergism of Essential Oil from Pericarp ofZanthoxylum schinifoliumand Verapamil.Evid Based Complement Alternat Med.2014;2014:1-8. doi:10.1155/2014/505876

[14] Lan Y, Li H, Chen Y yan, et al. Essential oil from Zanthoxylum bungeanum Maxim. and its main components used as transdermal penetration enhancers: a comparative study.J Zhejiang Univ Sci B.2014;15(11):940-952. doi:10.1631/jzus.B1400158

[15] Sun JS, Lin CY, Dong GC, et al. The effect of Gu-Sui-Bu (Drynaria fortunei J. Sm) on bone cell activities.
Biomaterials. 2002;23(16):3377-3385. doi: 10.1016/S0142-9612(02)00038-8

[16] Delshad E, Yousefi M, Sasannezhad P, Rakhshandeh H, Ayati Z. Medical uses of Carthamus tinctorius L. (Safflower): a comprehensive review from Traditional Medicine to Modern Medicine.Electron Physician.2018;10(4):6672-6681. doi:10.19082/6672

[17] Bensky D, Clavey S, Stoger E, Gamble A.Chinese Herbal Medicine: Materia Medica, Third Edition.3rd Edition. Eastland Press, Inc; 2004.

[18] Park JY, Park SD, Koh YJ, Kim DI, Lee JH. Aqueous extract of Dipsacus asperoides suppresses lipopolysaccharide-stimulated inflammatory responses by inhibiting the ERK1/2 signaling pathway in RAW 264.7 macrophages.J Ethnopharmacol.2019;231:253-261. doi:10.1016/j.jep.2018.11.010

[19] Chang NJ, Chen YW, Shieh DE, Fang HY, Shie MY. The effects of injectable calcium silicate-based composites with the Chinese herb on an osteogenic accelerator in vitro.
Biomed Mater.
2015;10(5):055004.
doi:10.1088/1748-6041/10/5/055004

[20] Yin B, Li W, Qin H, Yun J, Sun X. The Use of Chinese Skullcap (Scutellaria baicalensis) and Its Extracts for Sustainable Animal Production.Anim Open Access J MDPI.2021;11(4):1039. doi:10.3390/ani11041039

[21] Juan Liu, Cheng Peng, Qin-Mei Zhou, Li Guo, Zhao-Hua Liu, Liang Xiong, Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle, Phytochemistry, Volume 145, 2018, Pages 128-136, ISSN 0031-9422

[22] Adams JD Jr. The Use of California Sagebrush (Artemisia californica) Liniment to Control Pain. Pharmaceuticals. 2012; 5(10):1045-1053.

[23] Liu, J., Xiong, P., Huang, L., Zhang, W., Song, L., Hu, H., Jia, B., & Liu, X. (2023). Artemisia anomala S. Moore: A review of botany, traditional uses, phytochemistry, pharmacology and quality control. Journal of ethnopharmacology, 315, 116663.

[24] Saptarini, Nyi & Deswati, Dytha. (2021). Analgesic and Antipyretic Activities of Ethanolic Extract of Sappan wood (Caesalpinia sappan L.) Leaves. Research Journal of Pharmacy and Technology.

[25] Bell, R. F., Moreira, V. M., Kalso, E. A., & Yli-Kauhaluoma, J. (2021). Liquorice for pain?.
Therapeutic advances in psychopharmacology, 11, 20451253211024873.

[26] Nikkhah, Mehdi & Yousefi, Seyde-Sedighe & Pourmousa, Rostam & Fahimi, Ali & Seyfi, Fatemeh & Sadeghpour, Omid. (2021). Comparison of the effect of acetaminophen and licorice-based traditional medicine on reducing pain of patients undergoing denotonsillectomy, a pilot randomized clinical trial study. International journal of health sciences.

[27] Lin, H., Xie, Q., Huang, X., Ban, J., Wang, B., Wei, X., Chen, Y., & Lu, Z. (2018). Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery. International Journal of Nanomedicine, 13, 831–842.